Dallah al Baraka Group, property of al Baraka Banking and Investment Group chaired by Kamel, was named in a lawsuit put forward by families of victims of the 9/11 attacks. The plaintiffs alleged that subsidiaries of the group were involved in illicit Finance that aided extremists. Ultimately, all claims were subsequently dismissed in entirety by the U.S. District Court of Southern New York in 2005. Despite controversy surrounding his philanthropic work, the District Court ruled that Kamel has never knowingly abetted any extremist entities. Kamel has consistently stated that his company and philanthropic work remain committed to fostering dialogue and inter-religious understanding.

He owned the ART TV network, the only Sports channels that broadcast the FIFA world cup in the Middle East. In 2009 these Sports channels have been bought by the Al Jazeera Group.

He is Chairman of the Jeddah Chamber of Commerce and Industry as well as the Islamic Chamber of Commerce. Kamel has been called "the Father of contemporary Islamic finance", receiving Malaysia's Royal Award for Islamic Finance in November 2010. He is currently involved in efforts to significantly expand trade among member states of the Organization of Islamic Cooperation countries. Kamel is heavily involved in the promotion of Jeddah as a leading international port and hub for global commerce. In his capacity as chairman of DBHC and the JCC, he has led numerous projects to promote the Kingdom of Saudi Arabia as a regional economic force . Kamel has stated that his vision is to combine the efforts of his DBHC and the Chamber of commerce with ongoing mega-infrastructure projects such as King Abdullah Port, the Economic City, the new railways, and the King Abdullah International Airport to catalyze domestic Business across the Kingdom.

In his capacity as one of Saudi Arabia's leading businessmen, Kamel continues to actively promote philanthropy. In an interview with Arab News in 2012, Kamel estimated the total value of Islamic zakat in the Kingdom at SR 1 trillion. "Such a huge amount could be used to solve many economic and social problems in the country." He said that people should pay zakat for real estate properties that have been offered for sale. "We Muslims should understand the economic wisdom behind the system if we collect and use zakat properly for it can bring about substantial improvement in our economic conditions. If we had collected zakat from real estate property we would not have faced housing or land problems." He recalled discussing this matter with German Chancellor Angela Merkel. "I can tell you," he said that Islamic economics offers solutions for world problems." Referring to global economic crises he said they would not have occurred if we had implemented an Islamic Hadith by Muhammad which says, "Do not sell what you do not own or possess." In 2010, his son, CEO of DHBC, donated $10 million to Yale University to establish the Abdallah S. Kamel Center for the Study of Islamic Law and Civilization at Yale Law School

As of April 2016, Forbes estimated his net worth at US$2.1 billion. Saleh Kamel is the founder and chairman of Dallah Albaraka, a multi-national holding company with Investments including the financial, banking, Health care, real estate, Manufacturing, transportation, and operations and maintenance sectors.

On 4 November, 2017, Saleh Abdullah Kamel was arrested in Saudi Arabia in a "corruption crackdown" conducted by a new royal anti-corruption committee. This was done on authority of Crown Prince Mohammad bin Salman.