Secret Girlfriend was a first-person point of comedy series in which you (the viewer) interacted with other characters (your roommates, your crazy ex-girlfriend, your new 'Secret Girlfriend'). The series aired in October and November 2009 on Comedy Central, and each episode consists of two eleven-minute segments. Fletcher began her three-year-long journey to television series regular after she was cast in the earliest version of the show, a series of 10 'mobisodes' that ran on Sprint's cell phone media platform produced by Jay Rondot and Ross Novie for Fremantle Media. When Fremantle picked up 10 episodes for their website, atomicwedgietv.com, she again appeared as the titular character. Although the show was almost universally panned by critics, Fletcher herself was applauded for her performance as 'your' girlfriend. Time magazine praised her "spark and personality, for which she should get extra credit, having to spend 90% of her screen time pretending to be hot for a video camera."

Fletcher began appearing in a number of indie films in 2010 with A Numbers Game and The Hammer. She starred in iCrime as Carrie Kevin, a relative newcomer to Hollywood who makes a deal to expose the latest Internet cyber-lebrity as a fraud. Not surprisingly, the film was partially based on the experiences of Fletcher and writer/director Bears Fonte while promoting A$$ Wipers, Inc. and Scatting With Giselle a few years earlier. Although the film received mixed reviews, Fletcher was universally praised for performance. According to Jadedviewer, "Fletcher does such a good job of being the champion of anti-fakeiness it becomes addicting." LowNoBudgetReviews said "Fletcher does an especially great job carrying the weight of the film." Rock!Shock!Pop! said Fletcher "seems destined for bigger things... and she makes the film completely watchable even during the slower moments." Following iCrime, Fletcher appeared in several more indie features such as Beyond the Mat, Thirtyish, and The Asylum's version of Hansel & Gretel.

Fletcher has appeared in numerous television commercials, most notably a KFC ad in which she famously said "Game Day Bucket Go Boom!" She also played the bride in a Diet Pepsi ad starring Sophia Vergara. Fletcher received a bit of viral buzz when she played the lead subject in a 'social experiment' for Simple Pickup, appearing as a girl who looked one way in her Tinder profile, but quite different in real life. One week later the film, Fat Girl Tinder Date, had logged over 10,000,000 views on YouTube. In 2012, Fletcher worked on Resident Evil 6, providing the motion and facial capture performance for Sherry Birkin.

Fletcher has appeared in many other shorts and web series, several of which were produced by The Fine Brothers. She is currently a series regular on the first PBS digital narrative series, Frankenstein M.D., a modern, online video adaptation of Mary Shelley’s classic novel.