Sara Bettine Storer was born in October 1973 in Wemen where her parents, Lindsay and Fay Storer, farmed wheat and cattle on a 5,000 acres (2,000 ha) property. Her three brothers, including Doug and Greg Storer, became farmers, she also has two older sisters. She attended school in nearby, Robinvale.

When Sara Storer was 18, her parents moved from Wemen, Victoria to a farming property of 17,000 acres (6,900 ha), near Warren, New South Wales. Storer had lived in Melbourne, moved to Camooweal, North Queensland and then to Katherine and Kalkarindji, Northern Territory in the mid-1990s. By June 2009 Storer was living in Darwin. There she married David O'Hare, a cattle buyer, in April 2012 and the couple have four children. Storer took a break from song writing while focussing on parenting. O'Hare left Austrex in February 2014 after being their cattle export manager in Darwin for ten years.

Sara Storer released her first album, Chasing Buffalo, in August 2000 via ABC Music/Universal Music Australia with Porter producing. It peaked in the ARIA Albums Chart top 100, No. 20 on the Australasian Artists, No. 8 on the Hitseekers and No. 6 on the Country albums charts. She won the Best New Talent category at the 2001 Country Music Awards of Australia for her debut single, "Buffalo Bill", in January of that year.

Her second album, Beautiful Circle, appeared in November 2002, which was produced by Porter again. In January 2004 at the Country Music Awards of Australia she was nominated for eight Golden Guitars, and won seven of them – a then-record number of trophies at one ceremony: Vocal Collaboration, Single of the Year and Song of the Year all for "Raining on the Plains" (with John Williamson); Female Vocalist of the Year and Album of the Year for Beautiful Circle, Songwriter of the Year for "Raining on the Plains" (co-written with Porter and Greg Storer); Bush Ballad of the Year for "Boss Drovers Pride" and Heritage Song of the Year for "Drover's Call".

The album reached No. 50 on the ARIA Albums Chart in March 2004. It also peaked at No. 11 on the Australasian Artists, No. 1 on the Hitseekers and No. 2 on the Country albums charts. She promoted it by touring with Australian country singer, Troy Cassar-Daley, and United Kingdom singer, Charlie Landsborough, including playing to an audience of over 40,000 people at the Gympie Muster, Queensland. On 6 October 2004 she issued her first DVD, Stories to Tell, which included music videos, interview footage, acoustic performances and new tracks.

In December 2005 Deborah Conway established the Broad Festival project, "the idea that I would pull these different women performers together from different genres and call it Broad". Storer joined Conway, Katie Noonan, Ruby Hunter and Clare Bowditch where they performed their own and each other's songs on an Australian tour. Conway observed, "Sara you're a gorgeous surprise package, quiet and unassuming offstage; onstage, you had us pissing ourselves every night. I love that simple yet deceptive guitar playing and those haunting songs, which have such a piercing truth to them."

In March 2006 Storer played at the Queens' Lunch during the Melbourne Commonwealth Games. In February and March 2007 she performed a double-headlining tour with fellow country musician, Felicity Urquhart. In November of that year she provided her fourth studio album, Silver Skies, which reached the ARIA Albums Chart top 100 and No. 3 on the Country Albums Chart. It was co-produced by Cunningham and Matt Fell for her new label, EMI Records.

Its lead single, "Land Cries Out", appeared in September 2007, which Andrew Tijs of Undercover News described, "an achingly beautiful rumination on the bitterness of being forced to leave the land you love – an all too Common scenario during the recent drought. With this heartfelt subject matter, Storer has branched away from traditional country sounds... [she] uses electric guitar and drums to complement the lament." From late January to early February 2008 she supported a tour by American singer-songwriter, Suzanne Vega.

Storer had encouraged her brother Greg, a cropping farmer from "Strawin" 60 kilometres (37 mi) north-west of Warren, New South Wales, to write music, she has performed his work, including duets with him and she is recorded on his debut single, "When I Was a Boy" (December 2009). He recalled, "Sara started off telling me to write some lyrics and then every now and then she said I should get up and have a sing at one of her shows. It was absolutely terrifying to get up and sing in front of some great artists... [its] a bit addictive. The trick is to never put the guitar away – in between wrestling with the kids or doing something else, I can just pick up the guitar."

Storer released her first compilation album in April 2010, Calling Me Home – The Best of Sara Storer, which reached No. 28 on the ARIA Albums Chart and No. 1 on the Country Albums Chart. She had recorded three new tracks, "Calling Me Home", "Children of the Gurundi" (with Kev Carmody) and "Tears". At the ARIA Music Awards of 2010 John Williamson was inducted into their Hall of Fame in October, where Storer performed his tune, "Mallee Boy", in his honour.

The singer-songwriter launched her fifth album, Lovegrass, at the Gympie Music Muster in August 2013. She explained her preparation, "I'm getting there early and we're all going to catch up prior to the Muster for a rehearsal, which is a must especially when I'm releasing a new album and playing the songs with the band for the first time, really. We need a little practice run otherwise we could end up a train smash." Lovegrass, which was produced by Matt Fell, peaked at No. 25 on the ARIA Albums Chart and No. 5 on the Country Albums Chart. In 2015 Storer recorded "Song for Grace", a duet with Lee Kernaghan for his album, Spirit of the Anzacs (March 2015).

In March 2016 Storer released her sixth studio album, Silos, also produced by Fell, which peaked at No. 30 on the ARIA Albums Chart and No. 3 on the Country Music Albums Chart. It earned the musician her sixth nomination for ARIA Award for Best Country Album and her first win in the category, at that year's ceremony. At the Country Music Awards of Australia in January 2017 she received her 21st Golden Guitar – the most by any female Artist.

As of May 2017 the family has a farm near Bowna 33 kilometres (21 mi) from Albury, they also have a home in Albury. In January of that year she acknowledged her family when receiving her Golden Guitars at the Country Music Awards, "Dave has been a great support when I've gotten down about still doing this with four little boys. I have to thank my boys as well, for giving me a little moment every now and then to get a few lines down on paper."