Hubley was steadily active in supporting roles in the late 1970s and starred in Hardcore with George C. Scott. However, she is best known for her appearance as Priscilla Presley in the made-for-television film Elvis. She appeared briefly in Escape from New York. In 1973, she played the title character in Lolly-Madonna XXX, also known as The Lolly Madonna War, around whom the story revolved. It had to do with two battling backwoods families. Her other known film role is in the 1982 cult film Vice Squad, in which she played a prostitute named Princess.

In television, she made an appearance on The Partridge Family in 1972 playing the part of a Princess. In 1973, she starred as Pam in She Lives, a made-for-television movie about a young couple, co-starring Desi Arnaz, Jr. In 1977, she appeared as a nun whose sister was murdered in an episode of Kojak, and she had a continuing role in the evening TV drama Family. Hubley guest-starred in several episodes in 1976 and 1977 as Salina Magee, the love interest of teenage dropout Willie Lawrence. She also co-starred in an episode of Starsky and Hutch, "Starsky’s Lady", in which she was Starsky's (Paul Michael Glaser) fiancee. From 1991 to 1994, she portrayed Angelique Marick on the daytime drama All My Children. She appeared in Stepfather III and Child in the Night, both in 1990.

Hubley was married to actor Kurt Russell from 1979 to 1983. They have a son, Boston Oliver Grant Russell (born 1980).