The BET Awards were established in 2001 by the Black Entertainment Television (BET) network to celebrate African Americans in music, acting, Sports and other fields of entertainment. The awards are presented annually and broadcast live on BET. Rae Sremmurd had won one award from four nominations.

At the beginning of 2010, the group released the single "Party Animal", which gave them a local fame, allowing them to perform at these local festivals and to broadcast their tracks on local radios. Thanks to their savings, the group took part in the auditions of the "Wild Out Wednesday" segment on BET's show "106 & Park" in Memphis, Tennessee and succeeded to qualify. They participated on the December 8th show in New York City and performed "Party Animal". Later, the group met a young Rapper, named Andre "King Dre" Harris (today known as BoBo Swae), while he was freestyling in the high school courtyard. Andre originally from West Point, Mississippi, freshly arrived in Tupelo, and then started collaborating with the trio. Months later, the group finally released their first project, distributed locally.

In the middle of 2011, Lil Pantz left the group due to legal problems, and was replaced by Andre. Aaquil and Khalif took the opportunity to change their stage names from "CaliBoy" to "Weirdo" and from "King Krunk" to "Kid The Great". In August 2011, the trio once again participated to "106 & Park" and performed an original song "My Diddy". They finished second place overall in the competition, and arranged meetings with representatives from record labels Def Jam Recordings and Sony Music. However, they did not sign any record deals at that time.

Around this time, Jemarcus put the group in touch with Producer Pierre "P-Nazty" Slaughter, a cousin of his who had grown up in Tupelo but moved to Atlanta to work with Mike Will Made-It's record label, EarDrummers. P-Nazty appreciated the teenagers' music and decided to work with them. Thereby, the three Rappers left Tupelo and spent a few months with P-Nazty and - other EarDrummers Producer - Marquel "Marz" Middlebrooks in Georgia. They took the opportunity to perform in talent shows and recorded the track "I Dip", produced by Marz, and which increased their popularity a little more. They released their second project "Three Stooges Mixtape" at the beginning of 2012.

Rae Sremmurd was discovered by the major Hip Hop public in December 2013, due to their appearance on Mike Will's mixtape "#MikeWiLLBeenTriLL" on the track "We". The track was released as the duo's first promotional single two months later. They also released their second single, "Throw Sum Mo" in the same period. These two songs gave them the opportunity to perform at local clubs and to appear to radio.

In March, they participated in the South by Southwest music festival with Mike Will Made-It and performed their first official single, "No Flex Zone", for the first time. At the end of the month, the track was releasing to digital Retailers and progressively became viral. The music video of the song was released on August 11, with a guest appearance by American Comedian Mike Epps. Finally, the single entered the Billboard Hot 100 on the chart issue dated August 16 and peaked at number 36 on September 20. They also released a remix of the track featuring American Rappers Pusha T and Nicki Minaj which helped to increase its popularity. The group was invited to perform the hit single during 2014 BET Hip Hop Awards ceremony, their first performance at a major event.

At the end of 2015, "SremmLife" had been nominated by numerous magazine as one of the best albums of the year. Complex (magazine) even ranked the album as the third best of the year. This decision will cause a feud between the duo and Hot 97 radio presenter Ebro Darden, who considered that the album should not appear in this list.

SremmLife Crew Records is a record label founded by Rae Sremmurd in 2016. They signed Mississippi native Rappers with whom they worked before their major success. The label's first official release was the collective project Trail Mix in March, 2016, introducing all members of the crew.

In early 2018, Rae Sremmurd and Mike WiLL announced that Swae Lee and Slim Jxmmi would release their solo albums - Swaecation and Jxmtroduction - in the same package as SremmLife 3, as a triple album package called SR3MM. The duo released "T'd Up" as SremmLife 3's second single on February 5, 2018, and released three singles from SR3MM on March 1, 2018 - Swae Lee's "Hurt to Look", Slim Jxmmi's "Brxnks Truck", and the duo's "Powerglide" featuring previous collaborator Juicy J.

Shortly after, Bernadette Walker and her companion split up. Following the break-up, the two brothers started skipping school and working more seriously on music. They would return home at late hours, even when they had school the next morning. Their mother, fed up with their schedules, eventually kicked them out of her house, leaving them homeless. They began squatting in an abandoned house in the city with a friend of their stepdad’s. They took advantage of the opportunity and organized parties in their new home in order to spread their music.