In 1991, Jones entered the Queens-based rap group Onyx along with cousin Fredro Starr, Sonsee, and Big DS. In 1993 the group released their debut album entitled Bacdafucup. It proved to be a commercial success and eventually went multi-platinum, largely due to the well known single "Slam". Since then he has released four other albums with Onyx.

The 1994 Source Awards were never aired on television (as all subsequent Source Awards were), and it wasn't seen until 2008 when amateur footage of Sticky Fingaz shooting up the awards show was uploaded to YouTube. Before performing their hit single "Throw Ya Gunz", Sticky Fingaz fired off live rounds, and quickly disposed of the gun before authorities arrived.

He released his debut solo album in 2001 which was titled Black Trash: The Autobiography of Kirk Jones, a concept album that followed the (fictionalized) life of Kirk Jones in a story line fashion as he is released from prison and then ultimately his death. The album was a critical success being noted as very creative with substantial content, though it didn't gain much commercial recognition despite featuring well known artists such as Eminem, Raekwon, Redman and Canibus.

In 2003, he released his second album Decade "...but wait it gets worse" which was less well received by critics and gained even less mainstream acknowledgement, featuring on this album were performances from Fredro Starr & Omar Epps.

Jones was a regular on the short-lived UPN series Platinum as Grady Rhames. He also played the part of Pvt. Maurice "Smoke" Williams in the FX television series Over There, which depicts life as an American soldier in Iraq. He played Tyrone in Next Friday. Jones also played a recurring role as Kern Little, a gang leader and hiphop musician/producer on the FX series The Shield. He has also appeared in the direct-to-video and Sci-Fi Channel release House of the Dead II. Starting in 2006, Jones was cast as the half-human/half-vampire Blade in Blade: The Series, based on the Wesley Snipes movies, on Spike TV. The series was cancelled on September 29, 2006 through a press release from Spike. He has completed his work on a movie titled Karma, Confessions and Holi where he plays the character Rich Smooth. Jones was a major character in the remake of the movie Flight Of The Phoenix. In the video game Def Jam: Fight for NY he supplied his own voice and is one of the main antagonists throughout the story. He also has an appearance in the sequel, Def Jam: Icon, under the name Wink. He will be one of the character's friends until he is removed from his place as vice President. He recorded a public Service announcement for Deejay Ra's Hip-Hop Literacy campaign, encouraging reading about Jam Master Jay. Fingaz wrote, co-produced, co-directed and starred in the movie A Day in the Life. Fingaz starred in the movie Caught On Tape alongside Vivica A. Fox and Cedric the Entertainer.

Sticky Fingaz's brother Rapper X-1 died on July 4, 2007 In Las Vegas from a self-inflicted gunshot wound to the head.

In 2008 Jones launched his own label and film production company entitled Major Independents. The company has released and distributed several successful independent straight-to-DVD films.