Her professional acting began in 1999 with a role in The Audrey Hepburn Story, a made-for-television movie starring Jennifer Love Hewitt which was filmed in Montreal. For her work in The Sandy Bottom Orchestra (2000), she won a Young Artist Award for Best Performance in a TV Movie (Drama) in the category Supporting Young Actress. She had a lead role in the Disney Channel Original Movie Stepsister from Planet Weird. She then played Tilda Swinton's character's daughter in the film The Deep End.

She portrayed Elizabeth I in the HBO production The Royal Diaries: Elizabeth I. In an episode of Twice in a Lifetime in 2000, she played the younger version of Cloris Leachman's character. She had the title role in the Canadian-Australian co-production of Guinevere Jones. In the 2003 TV movie The Piano Man's Daughter, she portrayed a younger version of Stockard Channing's character. For her work in The Nickel Children, a film about teenage prostitution, she was awarded the Breakout Performance Award at the 2005 Method Fest Independent Film Festival. She was a regular cast member of Whistler in 2007, playing snowboarding champion Leah McLure (although she was not permitted to do her own stunts).

She enjoyed snowboarding, and as a teenager was a licensed snowboarding Teacher. She moved to Toronto in 2002.

In 2009, Hope was featured in the Modernista! ad campaign promoting the Palm Pre phone.

In addition to her acting career, Lindeman is active in the Toronto music scene, performing in Bruce Peninsula and leading her own band, The Weather Station. She was a nominee for the 2013 SOCAN Songwriting Prize for "Mule in the Flowers", a song she cowrote with Steve Lambke.

She recorded Loyalty, her third full-length album as The Weather Station, at La Frette studios in Paris, France with Afie Jurvanen of Bahamas and Robbie Lackritz, who has worked on albums with Bahamas, Feist, Zeus and Jason Collett. Loyalty was released on May 5, 2015 on Paradise of Bachelors (worldwide) and Outside Music (Canada).