Hall received her Bachelor of Arts in Broadcast Journalism from Temple University. She quickly moved to KTVT in Fort Worth, Texas. From 1997 to 2007, she worked for WFLD-TV in Chicago, Illinois. As a former Chicago resident, she frequently reported on issues related to Chicago politics. She held several positions at WFLD, which included general assignment reporter, consumer reporter, and she was the host of the three-hour segment "Fox News in the Morning". Tamron covered many "breaking news" stories at WFLD, including one of the most devastating accidents involving Amtrak in Illinois.

Hall was nominated for an Emmy for her consumer report segment, "The Bottom Line," which first aired in 1999. Tamron served as reporter of the NBC News segment "The Inauguration of Barack Obama," which was nominated for an Emmy in October, 2010. Hall received the Lew Klein Alumni in the Media award from Temple University in 2010. She also had another Emmy nomination for her segment called "Education Nation: Teacher Town Hall" in 2011. Tamron has also been featured in several major news publications, including ones by Ebony Magazine, Forbes, Huffington Post, and several others. She won an Edward R. Murrow Award for her report on domestic abuse in 2016.

In 2004, Renate, Hall's sister, was murdered, following bouts of domestic violence. Initially, officers informed Hall's family of their certainty of her attacker's identity. However, as of this writing, that person has not been brought to justice. During an interview at the Television Critics Association, Hall described the awful day when she received the call that her sister was found dead face down in her pool. She said there were many signals of domestic abuse that she realized at the time, but did not do anything to intervene, and she also partly blames herself for the loss of her sister.

Hall joined national news network MSNBC and NBC News in 2007. She also landed a one-on-one interview with Barack Obama before he announced his run for presidency in 2008.

At MSNBC, Hall served as a general reporter and fill-in anchor, first achieving prominence as a substitute anchor for Keith Olbermann on Countdown with Keith Olbermann. Hall then joined David Shuster as co-host of a two-hour program, The Big Picture, which premiered June 1, 2009, and concluded January 29, 2010. Hall anchored as a substitute for Natalie Morales, and also anchored on the weekends.

Hall was the host of NewsNation with Tamron Hall. News Nation was launched in 2010, and includes high-profile interviews and coverage of U.S., global and entertainment news. This segment airs weekdays from 2-3 p.m ET. News Nation has covered many important American events including a live television broadcast from Ground Zero in New York City after the death of Osama Bin Laden was declared. This segment also covered the final space shuttle launch in 2011 and also Hurricane Isaac in 2012. Tamron tries to encourage viewers to express their own opinions through Facebook and Twitter on prominent controversial news stories.

It was announced in July 2013 that Hall would host another series, Deadline: Crime With Tamron Hall, on Investigation Discovery. It debuted on September 1, 2013. The weekly newsmagazine series features two crime occurrences per episode with Hall and her investigative team digging deeper to uncover details on why/how things happened within each case. Tamron dedicates the series to her older sister, whose death was ruled a homicide in 2004, and remains unsolved. Hall's team is extremely diligent in their efforts, in and out of the studio, to retrieve information from as many reputable sources as possible in this one-hour program.

As of February 24, 2014, Hall was a co-anchor of Today's Take, the show's third hour with Natalie Morales, Al Roker and Willie Geist. On the March 20, 2015, Today show episode, Hall mentioned that she has often checked into hotels under the pseudonym DJ Warm Cookies. Hall is the first African American woman to co-anchor the Today show. On the day she signed the deal, she wore the jacket of American singer and civil rights Activist Lena Horne, which she bought from her estate sale. Horne remains a primary inspiration to Hall.

Tamron Hall was the 2017 Honorary Muse in the Krewe of Muses parade during Mardi Gras in New Orleans.