In her adolescence, she competed on the pageant circuit, winning the titles of Miss Teen Newhall (2000), Miss Teen Santa Clarita Valley (2001), and was voted Miss Congeniality at the 2001 Miss Teenage California pageant, where she was a Top 10 finalist.

While studying Theatre and Communications at College of the Canyons in Santa Clarita, CA, Tiffany continued performing in stage plays, as well as spearheaded the school's Speech & Debate Team. As the Speech & Debate team captain she competed, primarily, in Individual Events and won trophies nationally for her Dramatic Interpretation and Prose Interpretation performances. After two-years with the C.O.C. theatre program, then studying with UCLA's Film & Television Department, she embarked on a film and television career, booking roles on ER, Guilty or Innocent, Family Affair (2002 remake) and American Dreams.

One of Michelle's biggest roles, and most dramatic performances, came in 2005 when she starred opposite One Life to Live's David Fumero in the award winning independent film Carrie's Choice, based on a true story. The following year she landed a lead role in the horror film The Thirst: Blood War, starring Sean Connery's son, Jason Connery. The production was later halted and put on hold until 2008, at which point it was recast.

In 2006, she was heard nationwide on Sirius Satellite Radio as an on-air reporter for Bluff Magazine's live broadcast of the 2006 WSOP. In 2007, she became the first ever female hired as the resident, and full-time on-camera host for Pokernews.com,. She traveled the poker circuit internationally providing tournament updates, player interviews and red carpet coverage for poker tournaments and events worldwide, on the European Poker Tour, World Poker Tour, and World Series of Poker tours.

After a sabbatical from acting (2008–2012), Tiffany Michelle returned to the screen in early 2012 with appearances on Days of Our Lives and a guest-starring role on the award-winning soap opera series, DeVanity. In 2013, she wrote, produced and starred in the short film Breaking Up and Away. In 2014, Michelle return to the fourth and final season of DeVanity, as a series regular. She portrayed the resident villainess, Scarlett (Kane) DeVanity, the TV daughter of acclaimed Dallas actor Steve Kanaly.

With notoriety as a female professional poker player and competitive personality, Tiffany has been invited to compete on a variety of reality shows. In 2009, she missed the World Series of Poker Main Event to film the 15th season of the CBS seven-time Emmy Award winning reality show The Amazing Race. Alongside best friend and fellow poker player, Maria Ho the two made up the season's only all-female team and they traveled to Japan, Vietnam, Cambodia, Dubai, and The Netherlands, exiting the competition in 6th place. The show won the Emmy Award that season for Outstanding Reality-Competition Program.

Tiffany Michelle is also a singer/songwriter. She plays piano and guitar and has performed at several legendary Hollywood music venues, including BB Kings, and Hotel Cafe. In 2010, Tiffany headlined a special collaborative music show with guest performances by Celebrity music artists and friends, including Maria Ho, American Idol's Chikezie and 90210 actor, Ryan Eggold.

In 2012, Tiffany competed as one of 16 contestants on season three of Food Network's Worst Cooks in America. She was picked by chef Bobby Flay to compete as a member of his "Blue team." Tiffany won the Main Dish breakfast challenge in episode one as well as a pizza making Skill Drill in episode three. She made it down to the final three contestants on Bobby Flay's team and was sent home in episode six.

In 2013, she wrote, produced and starred in the short film Breaking Up and Away - also starring Zack Conroy and CariDee English.

In 2014, she was a series-regular (and resident villainess) on the Emmy nominated soap opera DeVanity.

In 2015, she returned to her on-camera poker hosting roots, as a guest host and sideline reporter for the Heartland Poker Tour.

One of few poker personalities to cross over into mainstream media, Michelle has been featured on the covers of Steppin’ Out Magazine, Ocean View Magazine, Rounder Magazine, and Casino Player Magazine.