She adapted the newspaper columns of John Diamond into a play called A Lump in my Throat, which was performed during the 2000 Edinburgh Festival at the Assembly Rooms, the Grace Theatre and the New End Theatre in London, before she adapted it again for a BBC Two docudrama with Neil Pearson, broadcast in 2001.

During her poker career she has become a close friend of The Hendon Mob, and mixes weekly home games with frequent visits to two regular casinos. She appeared in five episodes of Late Night Poker, although she never made it to a series grand final. However, in Late Night Poker's spin-off Celebrity Poker Club, she defeated Willie Thorne to win the series two grand final before joining Jesse May as the commentator in series three. In the 2003 Hold-Em 100 tournament in London she was a guest dealer for the final table.

On 24 September 2006 she won the main event of the European Poker Tour London earning a prize of £500,000 and defeating Australian professional Emad Tahtouh. On 20 November 2011 she finished second in the International Federation of Poker's inaugural The Table World Championship, eventually losing heads-up with 29-year-old Spaniard Raul Mestre. She received $100,000 for second place, $10,000 of which she donated to Age UK. In April 2014 she won the main event of the European Poker Tour San Remo, earning €476,100 and becoming the only player to have won two EPT titles. As of 2015 her total live tournament winnings exceed $2,400,000.

In December 2008 she revealed that in 2007 she had instigated a hoax to trap a group who turned up to memorial services for people they had never actually met. She created the fictitious and recently deceased Sir william Ormerod and placed an advertisement in the main British newspapers for his memorial Service "followed by a drinks reception". She reported that the group duly applied for tickets claiming to have known Ormerod.

Her poker memoir For Richer, For Poorer: A Love Affair with Poker (the subtitle changed to Confessions of a Player when released in paperback in 2011) was published in September 2009, and was well reviewed in The Times and The Observer.

On 20 March 2012 she announced her engagement to actor and Comedian David Mitchell. According to Mitchell they first met at a film premiere in 2007, but only began dating three years later. They married in November 2012, and Coren Mitchell gave birth to the couple's daughter in May 2015.

She has been a member of Team PokerStars Pro, but in November 2014 she removed her endorsement of them a few hours after PokerStars had announced they were starting an online casino. She said she was uncomfortable about potential addiction by vulnerable people to a site where the odds are in favour of the operator, and did not want to be associated with such an operation.

Coren Mitchell was inducted into the Women in Poker Hall of Fame in 2016.