Yeager was born February 13, 1923, to farming parents Susie Mae and Albert Hal Yeager in Myra, West Virginia, and graduated from high school in Hamlin, West Virginia, in June 1941. He had two brothers, Roy and Hal Jr., and two sisters, Doris Ann (accidentally killed at age 2 by 6-year-old Roy playing with a shotgun) and Pansy Lee. His first experience with the military was as a teen at the Citizens Military Training Camp at Fort Benjamin Harrison, Indianapolis, Indiana, during the summers of 1939 and 1940. On February 26, 1945, Yeager married Glennis Dickhouse, and the couple had four children. Glennis died in 1990.

Yeager enlisted as a private in the U.S. Army Air Forces (USAAF) on September 12, 1941, and became an aircraft mechanic at George Air Force Base, Victorville, California. At enlistment, Yeager was not eligible for FLIGHT training because of his age and educational background, but the entry of the U.S. into World War II less than three months later prompted the USAAF to alter its recruiting standards. Having unusually sharp vision (a visual acuity rated 20/10), which once enabled him to shoot a deer at 600 yards (550 m), Yeager displayed natural talent as a pilot and was accepted for FLIGHT training.

Yeager's career began in World War II as a private in the United States Army Air Forces. After serving as an aircraft mechanic, in September 1942 he entered enlisted pilot training and upon graduation was promoted to the rank of FLIGHT officer (the World War II USAAF equivalent to warrant officer) and became a P-51 fighter pilot.

He received his wings and a promotion to FLIGHT officer at Luke Field, Arizona, where he graduated from class 43C on March 10, 1943. Assigned to the 357th Fighter Group at Tonopah, Nevada, he initially trained as a fighter pilot, flying Bell P-39 Airacobras (being grounded for seven days for clipping a farmer's tree during a training flight), and shipped overseas with the group on November 23, 1943.

Yeager demonstrated outstanding flying skills and combat leadership. On October 12, 1944, he became the first pilot in his group to make "ace in a day," downing five enemy aircraft in a single mission. Two of these kills were scored without firing a single shot: when he flew into firing position against a Messerschmitt Bf 109, the pilot of the aircraft panicked, breaking to starboard and colliding with his wingman. Yeager said both pilots bailed out. He finished the war with 11.5 official victories, including one of the first air-to-air victories over a jet fighter, a German Messerschmitt Me 262 that he shot down on final approach for landing.

Yeager was commissioned a second lieutenant while at Leiston, and was promoted to captain before the end of his tour. He flew his 61st and final mission on January 15, 1945, and returned to the United States in early February. As an evader, he received his choice of assignments and, because his new wife was pregnant, chose Wright Field to be near his home in West Virginia. His high number of FLIGHT hours and maintenance experience qualified him to become a functional test pilot of repaired aircraft, which brought him under the command of Colonel Albert Boyd, head of the Aeronautical Systems FLIGHT Test Division.

Yeager broke the sound barrier on October 14, 1947, flying the X-1 at Mach 1.07 at an altitude of 45,000 ft (13,700 m). over the Rogers Dry Lake in the Mojave Desert. Yeager was awarded the MacKay and Collier Trophies in 1948 for his mach-transcending FLIGHT, and the Harmon International Trophy in 1954. The X-1 he flew that day was later put on permanent display at the Smithsonian Institution's National Air and Space Museum.

On November 20, 1953, the U.S. Navy program involving the D-558-II Skyrocket and its pilot, Scott Crossfield, became the first team to reach twice the speed of sound. After they were bested, Ridley and Yeager decided to beat rival Crossfield's speed record in a series of test flights that they dubbed "Operation NACA Weep." Not only did they beat Crossfield by setting a new record at Mach 2.44 on December 12, 1953, but they did it in time to spoil a celebration planned for the 50th anniversary of FLIGHT in which Crossfield was to be called "the fastest man alive."

The new record FLIGHT, however, did not entirely go to plan, since shortly after reaching Mach 2.44, Yeager lost control of the X-1A at about 80,000 ft (24,000 m) due to inertia coupling, a phenomenon largely unknown at the time. With the aircraft simultaneously rolling, pitching, and yawing out of control, Yeager dropped 51,000 feet (16,000 m) in less than a minute before regaining control at around 29,000 feet (8,800 m). He then managed to land without further incident. For this achievement, Yeager was awarded the Distinguished Service Medal (DSM) in 1954.

Yeager was foremost a fighter pilot and held several squadron and wing commands. From May 1955 to July 1957 he commanded the F-86H Sabre-equipped 417th Fighter-Bomber Squadron (50th Fighter-Bomber Wing) at Hahn AB, Germany, and Toul-Rosieres Air Base, France; and from 1957 to 1960 the F-100D Super Sabre-equipped 1st Fighter Day Squadron (later, while still under Yeager's command, re-designated the 306th Tactical Fighter Squadron) at George Air Force Base, California, and Morón Air Base, Spain.

Now a full colonel in 1962, after completion of a year's studies at the Air War College, Yeager became the first commandant of the USAF Aerospace Research Pilot School, which produced astronauts for NASA and the USAF, after its redesignation from the USAF FLIGHT Test Pilot School. (Yeager himself had only a high school education, so he was not eligible to become an Astronaut like those he trained.) Between December 1963 and January 1964, Yeager completed five flights in the NASA M2-F1 lifting body. An accident during a December 1963 test FLIGHT in one of the school's NF-104s eventually put an end to his record attempts.

In 1966 Yeager took command of the 405th Tactical Fighter Wing at Clark Air Base, the Philippines, whose squadrons were deployed on rotational temporary duty (TDY) in South Vietnam and elsewhere in Southeast Asia. There he accrued another 414 hours of combat time in 127 missions, mostly in a Martin B-57 Canberra light bomber. In February 1968, Yeager was assigned command of the 4th Tactical Fighter Wing at Seymour Johnson Air Force Base, North Carolina, and led the McDonnell Douglas F-4 Phantom II wing in South Korea during the Pueblo crisis.

On June 22, 1969, Yeager was promoted to brigadier general and was assigned in July as the vice-commander of the Seventeenth Air Force.

From 1971 to 1973, at the behest of Ambassador Joe Farland, Yeager was assigned to Pakistan to advise the Pakistan Air Force. In one of the numerous raids carried out by Indian pilots against Pakistani airfields, Yeager's plane was destroyed while it was parked at Islamabad airport. Edward C. Ingraham, a U.S diplomat who had served as political counselor to Ambassador Farland in Islamabad recalled this incident in the Washington Monthly of October, 1985: "After Yeager’s Beechcraft was destroyed during an Indian air raid, he raged to his cowering colleagues that the Indian pilot had been specifically instructed by Indira Gandhi to blast his plane. 'It was,' he later wrote, 'the Indian way of giving Uncle Sam the finger.'"

In 1973, Yeager was inducted into the National Aviation Hall of Fame, arguably aviation's highest honor. In December 1975, the U.S. Congress awarded Yeager a silver medal "equivalent to a noncombat Medal of Honor ... for contributing immeasurably to aerospace science by risking his life in piloting the XS-1 research airplane faster than the speed of sound on October 14, 1947." President Gerald Ford presented the medal to Yeager in a ceremony at the White House on December 8, 1976.

Yeager named his plane after his wife Glennis as a good-luck charm; "You're my good-luck charm, hon. Any airplane I name after you always brings me home". Yeager and Glennis moved to Grass Valley, California, after his retirement from the Air Force in 1975. The couple prospered because of Yeager's best-selling autobiography, speaking engagements and commercial ventures. Glennis Yeager died of ovarian cancer in 1990. They had four children (Susan, Don, Mickey and Sharon).

In the late 1980s and early 1990s, Yeager set several light general aircraft performance records for speed, range, and endurance. Most notable were flights conducted on behalf of Piper Aircraft. On one such FLIGHT, Yeager performed an emergency landing as a result of fuel exhaustion. On another, he piloted Piper's turboprop Cheyenne 400LS to a time-to-height record: FL350 (35,000 feet) in 16 minutes, exceeding the climb performance of a Boeing 737 at gross weight.

Yeager made a cameo appearance in the movie The Right Stuff (1983). He played "Fred," a bartender at "Pancho's Place", which was most appropriate, as Yeager said, "if all the hours were ever totaled, I reckon I spent more time at her place than in a cockpit over those years." His own role in the movie was played by Sam Shepard.

In his 1986 memoirs, Yeager recalled with disgust that "atrocities were committed by both sides" said he went on a mission with orders from the Eighth Air Force to "strafe anything that moved." During the mission briefing, he whispered to Major Donald H. Bochkay, "If we are going to do things like this, we sure as hell better make sure we are on the winning side." Yeager said, "I’m certainly not proud of that particular strafing mission against civilians. But it is there, on the record and in my memory." He has also expressed bitterness at his treatment in Britain during WWII, describing the British as "arrogant" and "nasty".

During this time Yeager also served as a technical adviser for three Electronic Arts FLIGHT simulator video games. The games include Chuck Yeager's Advanced FLIGHT Trainer, Chuck Yeager's Advanced FLIGHT Trainer 2.0, and Chuck Yeager's Air Combat. The game manuals featured quotes and anecdotes from Yeager, and were well received by players. Missions featured several of Yeager's accomplishments and let players attempt to top his records. Chuck Yeager's Advanced FLIGHT Trainer was Electronic Art's top selling game for 1987.

Yeager, who never attended college and was often modest about his background, is considered by many, including Flying Magazine, the California Hall of Fame, the State of West Virginia, National Aviation Hall of Fame, a few U.S. Presidents, and the United States Army Air Force, to be one of the greatest pilots of all time. Despite his lack of higher education, he has been honored in his home state. Marshall University has named its highest academic scholarship, the Society of Yeager Scholars, in his honor. Yeager was also the chairman of Experimental Aircraft Association's Young Eagle Program from 1994–2004, and has been named the program's chairman emeritus.

Yeager is fully retired from military test flying, after having maintained that status for three decades after his official retirement from the Air Force. On October 14, 1997, on the 50th anniversary of his historic FLIGHT past Mach 1, he flew a new Glamorous Glennis III, an F-15D Eagle, past Mach 1. The chase plane for the FLIGHT was an F-16 Fighting Falcon piloted by Bob Hoover, a longtime test and air show pilot who had been Yeager's wingman for the first supersonic FLIGHT. This was Yeager's last official FLIGHT with the U.S. Air Force. At the end of his speech to the crowd, Yeager concluded, "All that I am ... I owe to the Air Force." Later that month, he was the recipient of the Tony Jannus Award for his achievements.

In 2000, Yeager met Actress Victoria Scott D'Angelo on a hiking trail in Nevada County. The pair started dating shortly thereafter, and married in August 2003. Subsequent to the commencement of their relationship, a bitter dispute arose between Yeager, his children and D'Angelo. The children contended that D'Angelo, 41 years Yeager's junior, had married him for his fortune. Yeager and D'Angelo both denied the charge. Litigation ensued, in which his children accused D'Angelo of "undue influence" on Yeager, and Yeager accused his children of diverting hundreds of thousands of dollars from his pension fund. In August 2008, the California Court of Appeal ruled for Yeager, finding that his daughter Susan had breached her duty as trustee.

Yeager Airport in Charleston, West Virginia, is named in his honor. The Interstate 64/Interstate 77 bridge over the Kanawha River in Charleston is named in his honor. On October 19, 2006, the state of West Virginia also honored Yeager with a marker along Corridor G (part of U.S. 119) in his home Lincoln County, and also renamed part of the highway the Yeager Highway.

Yeager is an honorary board member of the humanitarian organization Wings of Hope. On August 25, 2009, Governor Schwarzenegger and Maria Shriver announced that Yeager would be one of 13 California Hall of Fame inductees in The California Museum's yearlong exhibit. The induction ceremony was on December 1, 2009, in Sacramento, California. Flying Magazine ranked Yeager number 5 on its 2013 list of The 51 Heroes of Aviation; he is the highest-ranked living person on the list.

On October 14, 2012, on the 65th anniversary of breaking the sound barrier, Yeager did it again at the age of 89, riding in a McDonnell Douglas F-15 Eagle piloted by Captain David Vincent out of Nellis Air Force Base.

Yeager remained in the Air Force after the war, becoming a test pilot at Muroc Army Air Field (now Edwards Air Force Base), following graduation from Air Materiel Command FLIGHT Performance School (Class 46C). After Bell Aircraft test pilot Chalmers "Slick" Goodlin demanded $150,000 ($1.6 million in 2015 dollars) to break the sound "barrier," the USAAF selected Yeager to fly the rocket-powered Bell XS-1 in a NACA program to research high-speed FLIGHT.