Houston and Chase then obtained the rights to the story of Dorothy Dandridge. Houston was to play Dandridge, the first African American Actress to be nominated for an Academy Award for Best Actress. Houston wanted the story told with dignity and honor. However, Halle Berry also had rights to the project and got her version going first. Later that year, Houston paid tribute to her idols, such as Aretha Franklin, Diana Ross, and Dionne Warwick, by performing their hits during the three-night HBO Concert Classic Whitney: Live from Washington, D.C.. The special raised over $300,000 for the Children's Defense Fund. Houston received the Quincy Jones Award for outstanding career achievements in the field of entertainment at the 12th Soul Train Music Awards.

Houston was a mezzo-soprano, and was commonly referred to as "The Voice" in reference to her exceptional vocal talent. She was third in MTV's list of 22 Greatest Voices, and sixth on Online Magazine COVE's list of the 100 Best Pop Vocalists with a score of 48.5/50. Jon Pareles of The New York Times stated she "always had a great big voice, a technical marvel from its velvety depths to its ballistic middle register to its ringing and airy heights". In 2008, Rolling Stone listed Houston as the thirty-fourth of the 100 greatest Singers of all time, stating, "Her voice is a mammoth, coruscating cry: Few vocalists could get away with opening a song with 45 unaccompanied seconds of singing, but Houston's powerhouse version of Dolly Parton's 'I Will Always Love You' is a tour de force." Matthew Perpetua from Rolling Stone also eulogized Houston's vocal, enumerating ten performances, including "How Will I Know" from the 1986 MTV VMAs and "The Star Spangled Banner" at the 1991 Super Bowl. "Whitney Houston was blessed with an astonishing vocal range and extraordinary technical skill, but what truly made her a great singer was her ability to connect with a song and drive home its drama and emotion with incredible precision", he stated. "She was a brilliant performer, and her live shows often eclipsed her studio recordings."

Whitney Houston was born on August 9, 1963, in what was then a middle-income neighborhood in Newark, New Jersey. She was the daughter of Army serviceman and entertainment executive John Russell Houston, Jr. (September 13, 1920 – February 2, 2003), and gospel singer Emily "Cissy" (Drinkard) Houston. Her elder brother Michael is a singer, and her elder half-brother is former basketball player Gary Garland. Her parents were both African American. Through her mother, Houston was a first cousin of Singers Dionne Warwick and Dee Dee Warwick. Her godmother was Darlene Love and her honorary aunt was Aretha Franklin, whom she met at age 8 or 9 when her mother took her to a recording studio. Houston was raised a Baptist, but was also exposed to the Pentecostal church. After the 1967 Newark riots, the family moved to a middle-class area in East Orange, New Jersey, when she was four. Her parents' marriage later ended in divorce.

The film's Soundtrack also enjoyed success. Houston executive-produced and contributed six songs for the motion picture's adjoining Soundtrack album. Rolling Stone said it is "nothing more than pleasant, tasteful and urbane". The soundtrack's lead single was "I Will Always Love You", written and originally recorded by Dolly Parton in 1974. Houston's version of the song was acclaimed by many critics, regarding it as her "signature song" or "iconic performance". Rolling Stone and USA Today called her rendition "the tour-de-force". The single peaked at number one on the Billboard Hot 100 for a then-record-breaking 14 weeks, number one on the R&B chart for a then-record-breaking 11 weeks, and number one on the Adult Contemporary charts for five weeks.

Houston spent some of her teenage years touring nightclubs where her mother, Cissy, was performing, and she would occasionally get on stage and perform with her. In 1977, at age 14, she became a backup singer on the Michael Zager Band's single "Life's a Party". In 1978, at age 15, Houston sang background vocals for Chaka Khan and Lou Rawls.

Stephen Holden of The New York Times said that Houston "revitalized the tradition of strong gospel-oriented pop-soul singing". Ann Powers of the Los Angeles Times referred to the singer as a "national treasure". Jon Caramanica, another music critic of The New York Times, called Houston "R&B's great modernizer", adding "slowly but surely reconciling the ambition and praise of the church with the movements and needs of the body and the glow of the mainstream". He also drew comparisons between Houston's influence and other big names' on 1980s pop:

Houston signed with Arista in 1983, but did not begin work on her album immediately. The label wanted to make sure no other label signed the singer away. Davis wanted to ensure he had the right material and producers for Houston's debut album. Some producers had to pass on the project because of prior commitments. Houston first recorded a duet with Teddy Pendergrass entitled "Hold Me" which appeared on his album, Love Language. The single was released in 1984 and gave Houston her first taste of success, becoming a Top 5 R&B hit. It would also appear on her debut album in 1985.

With production from Michael Masser, Kashif, Jermaine Jackson, and Narada Michael Walden, Houston's debut album Whitney Houston was released in February 1985. Rolling Stone magazine praised Houston, calling her "one of the most exciting new voices in years" while The New York Times called the album "an impressive, musically conservative showcase for an exceptional vocal talent". Arista Records promoted Houston's album with three different singles from the album in the US, UK and other European countries. In the UK, the dance-funk "Someone for Me", which failed to chart in the country, was the first single while "All at Once" was in such European countries as the Netherlands and Belgium, where the song reached the top 5 on the singles charts, respectively.

Houston won seven American Music Awards in total in 1986 and 1987, and an MTV Video Music Award. The album's popularity would also carry over to the 1987 Grammy Awards when "Greatest Love of All" would receive a Record of the Year nomination, ten years after the original recording of "The Greatest Love of All" by George Benson, which was the main theme of the boxer Muhammad Ali biopic "The Greatest" in 1977. Houston's debut album is listed as one of Rolling Stone's 500 Greatest Albums of All Time and on The Rock & Roll Hall of Fame's Definitive 200 list. Houston's grand entrance into the music industry is considered one of the 25 musical milestones of the last 25 years, according to USA Today. Following Houston's breakthrough, doors were opened for other African-American women such as Janet Jackson and Anita Baker to find notable success in popular music and on MTV.

With many expectations, Houston's second album, Whitney, was released in June 1987. The album again featured production from Masser, Kashif and Walden as well as Jellybean Benitez. Many critics complained that the material was too similar to her previous album. Rolling Stone said, "the narrow channel through which this talent has been directed is frustrating". Still, the album enjoyed commercial success. Houston became the first woman in music history to debut at number one on the Billboard 200 albums chart, and the first Artist to enter the albums chart at number one in both the US and UK, while also hitting number one or top ten in dozens of other countries around the world. The album's first single, "I Wanna Dance with Somebody (Who Loves Me)", was also a massive hit worldwide, peaking at No. 1 on the Billboard Hot 100 chart and topping the singles chart in many countries such as Australia, Germany and the UK. The next three singles, "Didn't We Almost Have It All", "So Emotional", and "Where Do Broken Hearts Go" all peaked at number one on the US Hot 100 chart, which gave her a total of seven consecutive number one hits, breaking the record of six previously shared by The Beatles and the Bee Gees. Houston became the first woman to generate four number-one singles from one album. Whitney has been certified 9× Platinum in the US for shipments of over 9 million copies, and has sold a total of 20 million copies worldwide.

Houston was a supporter of Nelson Mandela and the anti-apartheid movement. During her modeling days, the singer refused to work with any agencies who did Business with the then-apartheid South Africa. On June 11, 1988, during the European leg of her tour, Houston joined other Musicians to perform a set at Wembley Stadium in London to celebrate a then-imprisoned Nelson Mandela's 70th birthday. Over 72,000 people attended Wembley Stadium, and over a billion people tuned in worldwide as the rock concert raised over $1 million for charities while bringing awareness to apartheid. Houston then flew back to the US for a concert at Madison Square Garden in New York City in August. The show was a benefit concert that raised a quarter of a million dollars for the United Negro College Fund. In the same year, she recorded a song for NBC's coverage of the 1988 Summer Olympics, "One Moment in Time", which became a Top 5 hit in the US, while reaching number one in the UK and Germany. With her world tour continuing overseas, Houston was still one of the top 20 highest-earning entertainers for 1987–88 according to Forbes magazine.

With the success of her first two albums, Houston was undoubtedly an international crossover superstar, the most prominent since Michael Jackson, appealing to all demographics. However, some black critics believed she was "selling out". They felt her singing on record lacked the soul that was present during her live concerts. At the 1989 Soul Train Music Awards, when Houston's name was called out for a nomination, a few in the audience jeered. Houston defended herself against the criticism, stating, "If you're gonna have a long career, there's a certain way to do it, and I did it that way. I'm not ashamed of it."

After spending much of the early and mid-1990s working on motion pictures and their Soundtrack albums, Houston's first studio album in eight years, the critically acclaimed My Love Is Your Love, was released in November 1998. Though originally slated to be a greatest hits album with a handful of new songs, recording sessions were so fruitful that a new full-length studio album was released. Recorded and mixed in only six weeks, it featured production from Rodney Jerkins, Wyclef Jean and Missy Elliott. The album debuted at number thirteen, its peak position, on the Billboard 200 chart. It had a funkier and edgier sound than past releases and saw Houston handling urban dance, hip hop, mid-tempo R&B, reggae, torch songs, and ballads all with great dexterity.

Later in 1991, Houston put together her Welcome Home Heroes concert with HBO for the Soldiers fighting in the Persian Gulf War and their families. The free concert took place at Naval Station Norfolk in Norfolk, Virginia in front of 3,500 servicemen and women. HBO descrambled the concert so that it was free for everyone to watch. Houston's concert gave HBO its highest ratings ever. She then embarked on the I'm Your Baby Tonight World Tour.

The single was certified 4× platinum by the RIAA, making Houston the first woman with a single to reach that level in the RIAA history and becoming the best-selling single by a woman in the US. The song also became a global success, hitting number-one in almost all countries, and the best-selling single of all time by a female solo Artist with 20 million copies sold. The Soundtrack topped the Billboard 200 chart and remained there for 20 non-consecutive weeks, the longest tenure by any Arista album on the chart in the Nielsen SoundScan era (tied for 10th overall by any label), and became one of the fastest selling albums ever. During Christmas week of 1992, the Soundtrack sold over a million copies within a week, becoming the first album to achieve that feat under Nielsen SoundScan system. With the follow-up singles "I'm Every Woman", a Chaka Khan cover, and "I Have Nothing" both reaching the top five, Houston became the first woman to ever have three singles in the Top 11 simultaneously. The album was certified 18× platinum in the US alone, with worldwide sales of 45 million, making it the biggest-selling album by a female act on the list of the world's Top 10 best-selling albums.

Houston's vocal stylings have had a significant impact on the music industry. According to Linda Lister in Divafication: The Deification of Modern Female Pop Stars, she has been called the "Queen of Pop" for her influence during the 1990s, commercially rivaling Mariah Carey and Celine Dion. Stephen Holden from The New York Times, in his review of Houston's Radio City Music Hall concert on July 20, 1993, praised her attitude as a singer, writing, "Whitney Houston is one of the few contemporary pop stars of whom it might be said: the voice suffices. While almost every performer whose albums sell in the millions calls upon an entertainer's bag of tricks, from telling jokes to dancing to circus pyrotechnics, Ms. Houston would rather just stand there and sing." With regard to her singing style, he added: "Her [Houston's] stylistic trademarks – shivery melismas that ripple up in the middle of a song, twirling embellishments at the ends of phrases that suggest an almost breathless exhilaration – infuse her interpretations with flashes of musical and emotional lightning."

In October 1994, Houston attended and performed at a state dinner in the White House honoring newly elected South African President Nelson Mandela. At the end of her world tour, Houston performed three concerts in South Africa to honor President Mandela, playing to over 200,000 people. This would make the singer the first major musician to visit the newly unified and apartheid free nation following Mandela's winning election. The concert was broadcast live on HBO with funds of the concerts being donated to various charities in South Africa. The event was considered the nation's "biggest media event since the inauguration of Nelson Mandela".

In 1995, Houston starred alongside Angela Bassett, Loretta Devine, and Lela Rochon in her second film, Waiting to Exhale, a motion picture about four African-American women struggling with relationships. Houston played the lead character Savannah Jackson, a TV Producer in love with a married man. She chose the role because she saw the film as "a breakthrough for the image of black women because it presents them both as professionals and as caring mothers". After opening at number one and grossing $67 million in the US at the box office and $81 million worldwide, it proved that a movie primarily targeting a black audience can cross over to success, while paving the way for other all-black movies such as How Stella Got Her Groove Back and the Tyler Perry movies that became popular in the 2000s. The film is also notable for its portrayal of black women as strong middle class citizens rather than as stereotypes. The reviews were mainly positive for the ensemble cast. The New York Times said: "Ms. Houston has shed the defensive hauteur that made her portrayal of a pop star in 'The Bodyguard' seem so distant." Houston was nominated for an NAACP Image Award for "Outstanding Actress in a Motion Picture", but lost to her co-star Bassett.

Moments after news of her death emerged, CNN, MSNBC and Fox News all broke from their regularly scheduled programming to dedicate time to non-stop coverage of Houston's death. All three featured live interviews with people who had known Houston including those that had worked with her, interviewed her along with some of her peers in the music industry. Saturday Night Live displayed a photo of a smiling Houston, alongside Molly Shannon, from her 1996 appearance. MTV and VH-1 interrupted their regularly scheduled programming on Sunday February 12 to air many of Houston's classic videos with MTV often airing news segments in between and featuring various reactions from fans and celebrities.

In 1997, Houston's production company changed its name to BrownHouse Productions and was joined by Debra Martin Chase. Their goal was "to show aspects of the lives of African-Americans that have not been brought to the screen before" while improving how African-Americans are portrayed in film and television. Their first project was a made-for-television remake of Rodgers & Hammerstein's Cinderella. In addition to co-producing, Houston starred in the movie as the Fairy Godmother along with Brandy, Jason Alexander, Whoopi Goldberg, and Bernadette Peters. Houston was initially offered the role of Cinderella in 1993, but other projects intervened. The film is notable for its multi-racial cast and nonstereotypical message. An estimated 60 million viewers tuned into the special giving ABC its highest TV ratings in 16 years. The movie received seven Emmy nominations including Outstanding Variety, Musical or Comedy, while winning Outstanding Art Direction in a Variety, Musical or Comedy Special.

From late 1998 to early 2000, the album spawned several hit singles: "When You Believe" (US No. 15, UK No. 4), a duet with Mariah Carey for 1998's The Prince of Egypt Soundtrack, which also became an international hit as it peaked in the Top 10 in several countries and won an Academy Award for Best Original Song; "Heartbreak Hotel" (US No. 2, UK No. 25) featured Faith Evans and Kelly Price, received a 1999 MTV VMA nomination for Best R&B Video, and number one on the US R&B chart for seven weeks; "It's Not Right but It's Okay" (US No. 4, UK No. 3) won Houston her sixth Grammy Award for Best Female R&B Vocal Performance; "My Love Is Your Love" (US No. 4, UK No. 2) with 3 million copies sold worldwide; and "I Learned from the Best" (US No. 27, UK No. 19). These singles became international hits as well, and all the singles, except "When You Believe", became number one hits on the Billboard Hot Dance/Club Play chart. The album sold four million copies in America, making it certified 4× platinum, and a total of eleven million copies worldwide.

Mary J. Blige said that Houston inviting her onstage during VH1's Divas Live show in 1999 "opened doors for [her] all over the world". Brandy stated, "The first Whitney Houston CD was genius. That CD introduced the world to her Angelic yet powerful voice. Without Whitney, half of this generation of Singers wouldn't be singing." Kelly Rowland, in an Ebony's feature article celebrating black music in June 2006, recalled that "[I] wanted to be a singer after I saw Whitney Houston on TV singing 'Greatest Love of All'. I wanted to sing like Whitney Houston in that red dress." She added that "And I have never, ever forgotten that song [Greatest Love of All]. I learned it backward, forward, sideways. The video still brings chills to me. When you wish and pray for something as a kid, you never know what blessings God will give you."

Though Houston was seen as a "good girl" with a perfect image in the 1980s and early 1990s, her behavior had changed by the late 1990s. She was often hours late for interviews, photo shoots and rehearsals, and she canceled concerts and talk-show appearances. Missed performances and weight loss led to rumors about Houston using drugs with her husband. On January 11, 2000, airport security guards discovered marijuana in both Houston's and husband Bobby Brown's luggage at a Hawaii airport, but the two boarded the plane and departed before authorities could arrive. Charges were later dropped against them, but rumors of drug usage by Houston and Brown would continue to surface. Two months later, Clive Davis was inducted into the Rock & Roll Hall of Fame. Houston had been scheduled to perform at the event, but failed to show up.

In August 2001, Houston signed one of the biggest record deals in music history, with Arista/BMG. She renewed her contract for $100 million to deliver six new albums, on which she would also earn royalties. She later made an appearance on Michael Jackson: 30th Anniversary Special, where her extremely thin frame further spurred rumors of drug use. Houston's publicist said, "Whitney has been under stress due to family matters, and when she is under stress she doesn't eat." The singer was scheduled for a second performance the following night, but canceled it. Within weeks, Houston's rendition of "The Star Spangled Banner" would be re-released after the September 11 attacks, with the proceeds donated to the New York Firefighters 9/11 Disaster Relief Fund and the New York Fraternal Order of Police. The song peaked at No. 6 this time on the US Hot 100, topping its previous position.

In December 2002, Houston released her fifth studio album, Just Whitney. The album included productions from then-husband Bobby Brown, as well as Missy Elliott and Babyface, and marked the first time that Houston did not produce with Clive Davis as Davis had been released by top management at BMG. Upon its release, Just Whitney received mixed reviews. The album debuted at number 9 on the Billboard 200 chart and it had the highest first week sales of any album Houston had ever released. The four singles released from the album did not fare well on the Billboard Hot 100, but became dance chart hits. Just Whitney was certified platinum in the United States, and sold approximately three million worldwide.

In May 2003, Houston placed at number three on VH1's list of "50 Greatest Women of the Video Era", behind Madonna and Janet Jackson. She was also ranked at number 116 on their list of the "200 Greatest Pop Culture Icons of All Time". In 2008, Billboard magazine released a list of the Hot 100 All-Time Top Artists to celebrate the US singles chart's 50th anniversary, ranking Houston at number nine. Similarly, she was ranked as one of the "Top 100 Greatest Artists of All Time" by VH1 in September 2010. In November 2010, Billboard released its "Top 50 R&B/Hip-Hop Artists of the Past 25 Years" list and ranked Houston at number three who not only went on to earn eight number-one singles on the R&B/Hip-Hop Songs chart, but also landed five number ones on R&B/Hip-Hop Albums.

Houston's debut album is listed as one of the 500 Greatest Albums of All Time by Rolling Stone magazine and is on Rock and Roll Hall of Fame's Definitive 200 list. In 2004, Billboard picked the success of her first release on the charts as one of 110 Musical Milestones in its history. Houston's entrance into the music industry is considered one of the 25 musical milestones of the last 25 years, according to USA Today in 2007. It stated that she paved the way for Mariah Carey's chart-topping vocal gymnastics. In 1997, the Franklin School in East Orange, New Jersey was renamed to The Whitney E. Houston Academy School of Creative and Performing Arts. In 2001, Houston was the first Artist to be given a BET Lifetime Achievement Award. Houston is one of pop music's best-selling music artists of all-time, with an estimated 170–200 million records sold worldwide. She was ranked as the fourth best-selling female Artist in the United States by the Recording Industry Association of America, with 55 million certified albums sold in the US, and held an Honorary Doctorate in Humanities from Grambling State University, Louisiana. Houston was inducted into the New Jersey Hall of Fame in 2013. In August 2014, Houston was inducted to the official Rhythm and Blues Music Hall of Fame in its second class.

Houston struggled with vocal challenges during her later years. Gary Catona, a voice coach who began working with Houston in 2005, stated: "'When I first started working with her in 2005, she had lost 99.9 percent of her voice... She could barely speak, let alone sing. Her lifestyle choices had made her almost completely hoarse.'" After Houston's death, Catona said that Houston's voice had been damaged by her "extra-curricular activities"; Catona said, "The vocal mechanism is made up of skin tissue and muscle. It doesn't do well when it's abused by smoke . . . and other substances."

In March 2007, Clive Davis of Arista Records announced that Houston would begin recording a new album. In October 2007, Arista released another compilation entitled The Ultimate Collection outside the United States.

Houston gave her first interview in seven years in September 2009, appearing on Oprah Winfrey's season premiere. The interview was billed as "the most anticipated music interview of the decade". Whitney admitted on the show to having used drugs with former husband Bobby Brown during their marriage; Houston said Brown had "laced marijuana with rock cocaine". She told Oprah that before The Bodyguard her drug use was light, that she used drugs more heavily after the film's success and the birth of her daughter, and that by 1996 "[doing drugs] was an everyday thing... I wasn't happy by that point in time. I was losing myself." Houston told Oprah that she had attended a 30-day rehabilitation program. Houston also acknowledged to Oprah that her drug use had continued after rehabilitation, and that at one point, her mother obtained a court order and the assistance of law enforcement to press her into receiving further drug treatment. In her 2013 book, Remembering Whitney: My Story of Love, Loss, and the Night the Music Stopped, Cissy Houston described the scene she encountered at Whitney Houston’s house in 2005 as follows: “Somebody had spray-painted the walls and door with big glaring eyes and strange faces. Evil eyes, staring out like a threat... In another room there was a big framed photo of [Whitney] — but someone had cut [her] head out. It was beyond disturbing, seeing my daughter’s face cut out like that.” This visit led Cissy to return with law enforcement and perform an intervention. Houston also told Oprah that Bobby Brown had been emotionally abusive during their marriage, and had even spat on her on one occasion.

Houston was the most awarded female Artist of all time, according to Guinness World Records, with two Emmy Awards, six Grammy Awards, 30 Billboard Music Awards, 22 American Music Awards, among a total of 415 career awards as of 2010. She held the all-time record for the most American Music Awards of any female solo Artist and shared the record with Michael Jackson for the most AMAs ever won in a single year with eight wins in 1994. Houston won a record 11 Billboard Music Awards at its fourth ceremony in 1993. She also had the record for the most WMAs won in a single year, winning five awards at the 6th World Music Awards in 1994.

In May 2011, Houston enrolled in a rehabilitation center again, citing drug and alcohol problems. A representative for Houston said that the outpatient treatment was a part of Houston's "longstanding recovery process".

A number of artists have acknowledged Houston as an influence, including Celine Dion, Mariah Carey, Toni Braxton, Lady Gaga, Christina Aguilera, LeAnn Rimes, Jessica Simpson, Nelly Furtado, Kelly Clarkson, Britney Spears, Ciara, P!nk, Aneeka, Ashanti, Robin Thicke, Jennifer Hudson, Stacie Orrico, Amerie, Destiny's Child, and Ariana Grande. Mariah Carey, who was often compared to Houston, said, "She [Houston] has been a big influence on me." She later told USA Today that "none of us would sound the same if Aretha Franklin hadn't ever put out a record, or Whitney Houston hadn't." Celine Dion who was the third member of the troika that dominated female pop singing in the 1990s, did a telephone interview with Good Morning America on February 13, 2012, saying "Whitney's been an amazing inspiration for me. I've been singing with her my whole career, actually. I wanted to have a career like hers, sing like her, look beautiful like her." Beyoncé told the Globe and Mail that Houston "inspired [her] to get up there and do what [she] did". She also wrote on her website on the day after Houston's death, "I, like every singer, always wanted to be just like [Houston]. Her voice was perfect. Strong but soothing. Soulful and classic. Her vibrato, her cadence, her control. So many of my life's memories are attached to a Whitney Houston song. She is our queen and she opened doors and provided a blueprint for all of us."

Houston was considered by many to be a "singer's singer", who had an influence on countless other vocalists, both female and male. Similarly, Steve Huey from Allmusic wrote that the Shadow of Houston's prodigious technique still looms large over nearly every pop diva and smooth urban soul singer – male or female – in her wake, and spawned a legion of imitators. Rolling Stone, on her biography, stated that Houston "redefined the image of a female soul icon and inspired Singers ranging from Mariah Carey to Rihanna". Essence ranked Houston sixth on their list of 50 Most Influential R&B Stars of all time, calling her "the diva to end all divas".

On April 27, 2016, it was announced that a documentary film on Whitney Houston's life and death, entitled Whitney: Can I Be Me, was scheduled to be released in 2017. This was to be the first documentary on Houston that had been officially authorized by the estate. Advance publicity stated that the film would tell the story of the singer’s life, including access to never-before-seen footage of Houston, exclusive demo recordings, rare performances, and an audio archive. The film was released in 2017. It was co-produced and co-directed by Nick Broomfield.

The album I Wish You Love: More from The Bodyguard was released on November 17, 2017 to commemorate the 25th anniversary of The Bodyguard.