In 1978, she joined her then-boyfriend's band Baby Blue. They performed in local clubs in L.A. and once opened along with Rubber City Rebels for The Screamers' show at the Whisky a Go Go. The punk rock club The Masque served as a rehearsal place for the band. In 1978 they released a single "Rock n' Roll Rebel" with a b-side "Fantasy Man". Only 1000 copies of the record were made and distributed in England.

The band wasn't getting much attention, so they decided to promote it by posting her picture around town. In 1979, the single "Too Much to Touch" was released under the name Angelyne, also promoted by posters and flyers.

According to Angelyne, she met wealthy adhesive-free-tape Entrepreneur Hugo Maisnik (inventor of Hugo's Amazing Tape) in 1982. Maisnik had a display-printing Business in Los Angeles. Described as "very eccentric" and a "bored prankster", Maisnik reportedly saw potential in using Angelyne's image and understood the "intricacies of the outdoor-advertising game". In February 1984, Angelyne's first billboard proclaiming "Angelyne Rocks" went up on Sunset Boulevard. Maisnik's daughter Katherine Saltzberg, wrote the one-woman play, Los Angelyne, about her experience growing up in the Shadow of the Angelyne billboards.

In 1986, she released her second album, Driven to Fantasy, on her own label, Pink Kitten. An enhanced pink vinyl re-issue of the album was later released in Italy. In June 1987, an 85 feet high mural depicting Angelyne was painted on the side of a building on Hollywood and Vine. The $22,000 painting was allegedly financed by her manager. The same year, her friend Nina Hagen got her recording with Michael "Doc" Dosco, who had previously worked with Hagen on her album Nina Hagen in Ekstasy. He wrote and produced several songs for Angelyne, including "Animal Attraction", which was later featured in Julien Temple's movie Earth Girls Are Easy, where Angelyne had a cameo. The single was released in 1988 with remixes by Italian Producer Pino Toma. Hagen mentioned Angelyne in her song "Super Freak Family" and her voice can be heard in the song "Pillow Talk".

In 1995, a black-and-white documentary by Robinson Devor "Angelyne" was released. Around that time she had over 200 billboards up all over Los Angeles.

In 1997, Angelyne launched her website where she offered tours around Sunset Boulevard and Hollywood. The Angelyne Dream Experience, an experimental film by Dan Kapelovitz, who also worked on her EP Beauty & the Pink, was released in 1998. The short movie with elements of psychedelia features Angelyne driving in the streets of Los Angeles, greeting her fans and talking about out-of-body experience. The same year Angelyne pursued another artistic venture and began painting self-portraits. Since that she has had several successful art exhibitions.

After being a candidate for Hollywood city council in 2002 if it were to secede from Los Angeles, she ran again in 2003, this time for a governor of California. She finished 28th in a field of 135 candidates (garnering 2,536 votes). Her slogan during the campaign was "We've had Gray, we've had Brown, now it's time for some blond and pink." Her mascot was a pink Maltese named Budda.

In 2003 Angelyne became a candidate in the California governor recall election, finishing 28th in a field of 135 candidates (garnering 2,536 votes). Her slogan during the campaign was "We've had Gray, we've had Brown, now it's time for some blond and pink." Angelyne is also an Artist. She began painting in 1998 and has had several art shows in Los Angeles.

In July 2013, Angelyne signed a contract with designer Michael Kuluva to be a face of a limited edition T-shirt for his clothing line Tumbler and Tipsy.

Her previous name as well as her origins became publicly known in a 2017 article by Gary Baum for The Hollywood Reporter. The article cited public records revealing that Angelyne was born to Holocaust survivors who, after being liberated from Skarżysko-Kamienna German Nazi concentration camps, returned to post-war Poland and later settled in Israel, before finally immigrating to the United States, moving to the Fairfax District of Los Angeles. Goldberg attended James Monroe High School and was married briefly.