Aurangzeb was born on 3 November 1618, in Dahod, Gujarat. He was the third son and sixth child of Shah Jahan and Mumtaz Mahal. In June 1626, after an unsuccessful rebellion by his father, Aurangzeb and his brother Dara Shukoh were kept as hostages under their grandparents' (Nur Jahan and Jahangir) Lahore court. On 26 February 1628, Shah Jahan was officially declared the Mughal Emperor, and Aurangzeb returned to live with his parents at Agra Fort, where Aurangzeb received his formal education in Arabic and Persian. His daily allowance was fixed at Rs. 500, which he spent on religious education and the study of history.

On 28 May 1633, Aurangzeb escaped death when a powerful war elephant stampeded through the Mughal Imperial encampment. He rode against the elephant and struck its trunk with a lance, and successfully defended himself from being crushed. Aurangzeb's valour was appreciated by his father who conferred him the title of Bahadur (Brave) and had him weighed in gold and presented gifts worth Rs. 200,000. This event was celebrated in Persian and Urdu verses, and Aurangzeb said:

Aurangzeb was nominally in charge of the force sent to Bundelkhand with the intent of subduing the rebellious ruler of Orchha, Jhujhar Singh, who had attacked another territory in defiance of Shah Jahan's policy and was refusing to atone for his actions. By arrangement, Aurangzeb stayed in the rear, away from the fighting, and took the advice of his generals as the Mughal Army gathered and commenced the Siege of Orchha in 1635.The campaign was successful and Singh was removed from power.

Aurangzeb was appointed viceroy of the Deccan in 1636. After Shah Jahan's vassals had been devastated by the alarming expansion of Ahmednagar during the reign of the Nizam Shahi boy-prince Murtaza Shah III, the Emperor dispatched Aurangzeb, who in 1636 brought the Nizam Shahi dynasty to an end. In 1637, Aurangzeb married the Safavid Princess Dilras Banu Begum, posthumously known as Rabia-ud-Daurani. She was his first wife and chief consort as well as his favourite. He also had an infatuation with a slave girl, Hira Bai, whose death at a young age greatly affected him. In his old age, he was under the charms of his concubine, Udaipuri Bai. The latter had formerly been a companion to Dara Shukoh. In the same year, 1637, Aurangzeb was placed in charge of annexing the small Rajput kingdom of Baglana, which he did with ease.

In 1644, Aurangzeb's sister, Jahanara, was burned when the chemicals in her perfume were ignited by a nearby lamp while in Agra. This event precipitated a family crisis with political consequences. Aurangzeb suffered his father's displeasure by not returning to Agra immediately but rather three weeks later. Shah Jahan had been nursing Jahanara back to health in that time and thousands of vassals had arrived in Agra to pay their respects. Shah Jahan was outraged to see Aurangzeb enter the interior palace compound in military attire and immediately dismissed him from his position of viceroy of the Deccan; Aurangzeb was also no longer allowed to use red tents or to associate himself with the official military standard of the Mughal Emperor. Other sources tell us that Aurangzeb was dismissed from his position because Aurangzeb left the life of luxury and became a Faqir.

In 1645, he was barred from the court for seven months and mentioned his grief to fellow Mughal commanders. Thereafter, Shah Jahan appointed him governor of Gujarat where he served well and was rewarded for bringing stability.

In 1647, Shah Jahan moved Aurangzeb from Gujarat to be governor of Balkh, replacing a younger son, Murad Baksh, who had proved ineffective there. The area was under attack from Uzbek and Turkmen tribes. Whilst the Mughal artillery and muskets were a formidable force, so too were the skirmishing skills of their opponents. The two sides were in stalemate and Aurangzeb discovered that his army could not live off the land, which was devastated by war. With the onset of winter, he and his father had to make a largely unsatisfactory deal with the Uzbeks, giving away territory in exchange for nominal recognition of Mughal sovereignty. The Mughal force suffered still further with attacks by Uzbeks and other tribesmen as it retreated through snow to Kabul. By the end of this two-year campaign, into which Aurangzeb had been plunged at a late stage, a vast sum of money had been expended for little gain.

Further inauspicious military involvements followed, as Aurangzeb was appointed governor of Multan and Sindh. His efforts in 1649 and 1652 to dislodge the Safavids at Kandahar, which they had recently retaken after a decade of Mughal control, both ended in failure as winter approached. The logistical problems of supplying an army at the extremity of the empire, combined with the poor quality of armaments and the intransigence of the opposition have been cited by John Richards as the reasons for failure, and a third attempt in 1653, led by Dara Shikoh, met with the same outcome.

In 1656, a general under Qutb Shahi dynasty named Musa Khan led an army of 12,000 Musketeers to attack Aurangzeb, and later on the same campaign Aurangzeb in turn rode against an army consisting 8,000 horsemen and 20,000 Karnataka Musketeers

In 1657, while Aurangzeb attacked Golconda and Bijapur in the Deccan, the Hindu Maratha warrior aristocrat, Shivaji, used guerrilla tactics to take control of three Adil Shahi forts formerly under his father's command. With these victories, Shivaji assumed de facto leadership of many independent Maratha clans. The Marathas harried the flanks of the warring Adil Shahis and Mughals, gaining weapons, forts, and territory. Shivaji's small and ill-equipped army survived an all out Adil Shahi attack, and Shivaji personally killed the Adil Shahi general, Afzal Khan. With this event, the Marathas transformed into a powerful military force, capturing more and more Adil Shahi and Mughal territories. Shivaji went on to neutralise Mughal power in the region.

Subhan Quli, Balkh's Uzbek ruler was the first to recognise him in 1658 and requested for a general alliance, he worked alongside the new Mughal Emperor since 1647, when Aurangzeb was the Subedar of Balkh.

In 1659, Aurangzeb sent his trusted general and maternal uncle Shaista Khan, the Wali in Golconda to recover forts lost to the Maratha rebels. Shaista Khan drove into Maratha territory and took up residence in Pune. But in a daring raid on the governor's palace in Pune during a midnight wedding celebration, led by Shivaji himself, the Marathas killed Shaista Khan's son and Shivaji maimed Shaista Khan by cutting off three fingers of his hand. Shaista Khan, however, survived and was re-appointed the administrator of Bengal going on to become a key commander in the war against the Ahoms.

While Aurangzeb and his brother Shah Shuja had been fighting against each other, the Hindu rulers of Kuch Behar and Assam took advantage of the disturbed conditions in the Mughal Empire, had invaded imperial dominions. For three years they were not attacked, but in 1660 Mir Jumla II, the viceroy of Bengal, was ordered to recover the lost territories.

Aurangzeb then broke his arrangement with Murad Baksh, which probably had been his intention all along. Instead of looking to partition the empire between himself and Murad, he had his brother arrested and imprisoned at Gwalior Fort. Murad was executed on 4 December 1661, ostensibly for the murder of the diwan of Gujarat some time earlier. The allegation was encouraged by Aurangzeb, who caused the diwan's son to seek retribution for the death under the principles of Sharia law. Meanwhile, Dara gathered his forces, and moved to the Punjab. The army sent against Shuja was trapped in the east, its generals Jai Singh and Dilir Khan submitted to Aurangzeb, but Dara's son, Suleiman Shikoh, escaped. Aurangzeb offered Shah Shuja the governorship of Bengal. This move had the effect of isolating Dara Shikoh and causing more troops to defect to Aurangzeb. Shah Shuja, who had declared himself Emperor in Bengal began to annex more territory and this prompted Aurangzeb to march from Punjab with a new and large army that fought during the Battle of Khajwa, where Shah Shuja and his chain-mail armoured war elephants were routed by the forces loyal to Aurangzeb. Shah Shuja then fled to Arakan (in present-day Burma), where he was executed by the local rulers.

The Mughals set out in November 1661, and within weeks occupied the capital of Kuch Behar after a few fierce skirmishes. The Kuch Behar was annexed, and the Mughal Army reorganised and began to retake their territories in Assam. Mir Jumla II's forces captured Pandu, Guwahati, and Kajali practically unopposed. In February 1662, Mir Jumla II initiated the Siege of Simalugarh and after the Mughal cannon breached the fortifications, the Ahoms abandoned the fort and escaped. Mir Jumla II then proceeded towards Garhgaon the capital of the Ahom kingdom, which was reached on 17 March 1662, although the ruler Raja Sutamla fled and the victorious Mughals captured 100 elephants, about 300,000 coins of silver, 8000 shields, 1000 ships, and 173 massive stores of rice.

Later that year in December 1663, the aged Mir Jumla II died on his way back to Dacca of natural causes, but skirmishes continued between the Mughals and Ahoms after the rise of Chakradhwaj Singha, who refused to pay further indemnity to the Mughals and during the wars that continued the Mughals suffered great hardships. Munnawar Khan emerged as a leading figure and is known to have supplied food to vulnerable Mughal forces in the region near Mathurapur. Although the Mughals under the command of Syed Firoz Khan the Faujdar at Guwahati were overrun by two Ahom armies in 1667, but they continued to hold and maintain presence in their eastern territories even after the Battle of Saraighat in 1671.

In 1664, Aurangzeb appointed Shaista Khan subedar (governor) of Bengal. Shaista Khan eliminated Portuguese and Arakanese pirates from the region, and in 1666 recaptured the port of Chittagong from the Arakanese king, Sanda Thudhamma. Chittagong remained a key port throughout Mughal rule.

In 1667, the French East India Company ambassadors Le Gouz and Bebert presented Louis XIV of France's letter which urged the protection of French merchants from various rebels in the Deccan. In response to the letter Aurangzeb issued a Firman allowing the French to open a factory in Surat.

In 1669, Hindu Jats began to organise a rebellion that is believed to have been caused by Aurangzeb's imposition of Jizya (a form of organised religious taxation). The Jats were led by Gokula, a rebel landholder from Tilpat. By the year 1670 20,000 Jat rebels were quelled and the Mughal Army took control of Tilpat, Gokula's personal fortune amounted to 93,000 gold coins and hundreds of thousands of silver coins.

Early in Aurangzeb's reign, various insurgent groups of Sikhs engaged Mughal troops in increasingly bloody battles. The ninth Sikh Guru, Guru Tegh Bahadur, like his predecessors was opposed to conversion of the local population as he considered it wrong. According to Sikh sources, approached by Kashmiri Pandits to help them retain their faith and avoid forced religious conversions, Guru Tegh Bahadur took on Aurangzeb. The Emperor perceived the rising popularity of the Guru as a threat to his sovereignty and in 1670 had him executed, which infuriated the Sikhs. In response, Guru Tegh Bahadur's son and successor, Guru Gobind Singh, further militarised his followers, starting with the establishment of Khalsa in 1699, eight years before Aurangzeb's death. In 1705, Guru Gobind Singh sent a letter entitled Zafarnamah to Aurangzeb. This drew attention to Aurangzeb's cruelty and how he had betrayed Islam. The letter caused him much distress and remorse. Guru Gobind Singh's formation of Khalsa in 1699 led to the establishment of the Sikh Confederacy and later Sikh Empire.

The Battle of Saraighat was fought in 1671 between the Mughal empire (led by the Kachwaha king, Raja Ramsingh I), and the Ahom Kingdom (led by Lachit Borphukan) on the Brahmaputra river at Saraighat, now in Guwahati. Although much weaker, the Ahom Army defeated the Mughal Army by brilliant uses of the terrain, clever diplomatic negotiations to buy time, guerrilla tactics, psychological warfare, military intelligence and by exploiting the sole weakness of the Mughal forces—its navy.

The Pashtun revolt in 1672 under the leadership of the warrior poet Khushal Khan Khattak of Kabul, was triggered when Soldiers under the orders of the Mughal Governor Amir Khan allegedly molested women of the Pashtun tribes in modern-day Kunar Province of Afghanistan. The Safi tribes retaliated against the Soldiers. This attack provoked a reprisal, which triggered a general revolt of most of tribes. Attempting to reassert his authority, Amir Khan led a large Mughal Army to the Khyber Pass, where the army was surrounded by tribesmen and routed, with only four men, including the Governor, managing to escape.

After that the revolt spread, with the Mughals suffering a near total collapse of their authority in the Pashtun belt. The closure of the important Attock-Kabul trade route along the Grand Trunk road was particularly disastrous. By 1674, the situation had deteriorated to a point where Aurangzeb camped at Attock to personally take charge. Switching to diplomacy and bribery along with force of arms, the Mughals eventually split the rebels and partially suppressed the revolt, although they never managed to wield effective authority outside the main trade route.

In 1675 the Sikh leader Guru Tegh Bahadur was arrested on orders by Aurangzeb, found guilty of blasphemy by a Qadi's court and executed.

Aurangzeb thought of changing the name of Hindu's one of the holiest city Benaras to Muhammadabad. Among the Hindu temples he demolished were three of the most sacred, the Kashi Vishwanath temple, Kesava Deo temple, and Somnath temple, and built large mosques in their place. In 1679, he ordered destruction of several prominent temples that had become associated with his enemies: these included the temples of Khandela, Udaipur, Chittor and Jodhpur. The Historian Richard Eaton argues that the overall understanding of temples to be flawed. As early as the sixth century, temples became vital political landmarks as well as religious ones. He writes that, not only was temple desecration widely practised and accepted, it was a necessary part of political struggle.

The Battle of Saraighat was the last battle in the last major attempt by the Mughals to extend their empire into Assam. Though the Mughals managed to regain Guwahati briefly after a later Borphukan deserted it, the Ahoms wrested control in the Battle of Itakhuli in 1682 and maintained it till the end of their rule.

In 1686, the East India Company, which had unsuccessfully tried to obtain a firman, an imperial directive that would grant England regular trading privileges throughout the Mughal empire, initiated the so-called Child's War. This hostility against the empire ended in disaster for the English, particularly when Aurangzeb dispatched a strong fleet from Janjira commanded by the Sidi Yaqub and manned by Mappila loyal to Ali Raja Ali II and Abyssinian sailors blockaded Bombay in 1689. In 1690, the company sent envoys to Aurangzeb's camp to plead for a pardon. The company's envoys had to prostrate themselves before the Emperor, pay a large indemnity, and promise better behaviour in the Future.

Only one remaining ruler, Abul Hasan Qutb Shah (the Qutbshahi ruler of Golconda), refused to surrender. He and his servicemen fortified themselves at Golconda and fiercely protected the Kollur Mine, which was then probably the world's most productive Diamond mine, and an important economic asset. In 1687, Aurangzeb led his grand Mughal army against the Deccan Qutbshahi fortress during the Siege of Golconda. The Qutbshahis had constructed massive fortifications throughout successive generations on a granite hill over 400 ft high with an enormous eight-mile long wall enclosing the city. The main gates of Golconda had the ability to repulse any war elephant attack. Although the Qutbshahis maintained the impregnability of their walls, at night Aurangzeb and his infantry erected complex scaffolding that allowed them to scale the high walls. During the eight-month siege the Mughals faced many hardships including the death of their experienced commander Kilich Khan Bahadur. Eventually, Aurangzeb and his forces managed to penetrate the walls by capturing a gate, and their entry into the fort led Abul Hasan Qutb Shah to surrender peacefully.

In 1688, the desperate Ottoman Sultan Suleiman II urgently requested for assistance against the rapidly advancing Austrians, during the Ottoman–Habsburg War. However, Aurangzeb and his forces were heavily engaged in the Deccan Wars against the Marathas to commit any formal assistance to their Ottoman allies.

By 1689, almost all of Southern India was a part of the Mughal Empire and after the conquest of Golconda, Mughal victories in the south expanded the Mughal Empire to 4 million square kilometres, with a population estimated to be over 158 million. But this supremacy was short-lived. Jos Gommans, Professor of Colonial and Global History at the University of Leiden, says that "... the highpoint of imperial centralisation under Emperor Aurangzeb coincided with the start of the imperial downfall."

Aurangzeb was a notable expansionist and during his reign, the Mughal Empire reached its greatest extent, ruling over nearly all of the Indian subcontinent. During his lifetime, victories in the south expanded the Mughal Empire to 4 million square kilometres, and he ruled over a population estimated to be over 158 million subjects, with an annual yearly revenue of $450 million (more than ten times that of his contemporary Louis XIV of France), or £38,624,680 (2,879,469,894 rupees) in 1690. Under his reign, India surpassed China once again to become the world's largest economy, worth over $90 billion, nearly a quarter of world GDP in 1700.

In September 1695, English pirate Henry Every perpetrated one of the most profitable pirate raids in history with his capture of a Grand Mughal convoy near Surat. The Indian ships had been returning home from their annual pilgrimage to Mecca when the pirates struck, capturing the Ganj-i-Sawai, reportedly the greatest ship in the Muslim fleet, and its escorts in the process. When news of the piracy reached the mainland, a livid Aurangzeb nearly ordered an armed attack against the English-governed city of Bombay, though he finally agreed to compromise after the East India Company promised to pay financial reparations, estimated at £600,000 by the Mughal authorities. Meanwhile, Aurangzeb shut down four of the East India Company's factories, imprisoned the workers and captains (who were nearly lynched by a rioting mob), and threatened to put an end to all English trading in India until Every was captured. The Privy Council and East India Company offered a massive bounty for Every's apprehension, leading to the first worldwide manhunt in recorded history. However, Every successfully eluded capture.

By 1700, the Marathas attacked the Mughal provinces from the Deccan and secessionist agendas from the Rajputs, Hindu Jats, Pashtuns and Sikhs rebelled against the Mughal Empire's administrative and economic systems.

In 1702, Aurangzeb sent Daud Khan Panni, the Mughal Empire's Subhedar of the Carnatic region, to besiege and blockade Fort St. George for more than three months. The governor of the fort Thomas Pitt was instructed by the East India Company to sue for peace.

In 1703, the Mughal commander at Coromandel, Daud Khan Panni spent 10,500 coins to purchase 30 to 50 war elephants from Ceylon.

Many Indian historians consider his death year 1707 as the one which marks the end of Medieval Indian history and the start of Modern Indian history when classifying Indian history. This is because of the start of decline of the Mughal empire and the start of domination of European powers in India.

Brown writes that after his death, "a string of weak emperors, wars of succession, and coups by noblemen heralded the irrevocable weakening of Mughal power". She notes that the populist but "fairly old-fashioned" explanation for the decline is that there was a reaction to Aurangzeb's oppression. Aurangzeb's son, Bahadur Shah I, succeeded him and the empire, both because of Aurangzeb's over-extension and because of Bahadur Shah's weak military and leadership qualities, entered a period of terminal decline. Immediately after Bahadur Shah occupied the throne, the Maratha Empire – which Aurangzeb had held at bay, inflicting high human and monetary costs even on his own empire – consolidated and launched effective invasions of Mughal territory, seizing power from the weak Emperor. Within decades of Aurangzeb's death, the Mughal Emperor had little power beyond the walls of Delhi.

During British rule of India, a road in Delhi was named Aurangzeb road. In November 2014, it was renamed to Dr APJ Abdul Kalam Road.

Mughal cannon making skills advanced during the 17th century. One of the most impressive Mughal cannons is known as the Zafarbaksh, which is a very rare composite cannon, that required skills in both wrought-iron forge welding and bronze-casting technologies and the in-depth knowledge of the qualities of both metals.